Background: Fire strongly affects animals’ behavior, population dynamics, and environmental surroundings, which in turn are likely to affect their immune systems and exposure to pathogens. However, little work has yet been conducted on the effects of wildfires on wildlife disease. This research gap is rapidly growing in importance because wildfires are becoming globally more common and more severe, with unknown impacts on wildlife disease and unclear implications for livestock and human health in the future.

Results: Here, we discussed how wildfires could influence susceptibility and exposure to infection in wild animals, and the potential consequences for ecology and public health. In our framework, we outlined how habitat loss and degradation caused by fire affect animals’ immune defenses, and how behavioral and demographic responses to fire affect pathogen exposure, spread, and maintenance. We identified relative unknowns that might influence disease dynamics in unpredictable ways (e.g., through altered community composition and effects on free-living parasites). Finally, we discussed avenues for future investigations of fire-disease links.

Conclusions: We hope that this review will stimulate much-needed research on the role of wildfire in influencing wildlife disease, providing an important source of information on disease dynamics in the wake of future wildfires and other natural disasters, and encouraging further integration of the fields of fire and disease ecology.