The Integrated Rangeland Fire Management Strategy (hereafter Strategy, DOI 2015) outlined the need for coordinated, science-based adaptive management to achieve long-term protection, conservation, and restoration of the sagebrush (Artemisia spp.) ecosystem. A key component of this management approach is the identification of knowledge gaps that limit implementation of effective strategies to meet current management challenges. The tasks and actions identified in the Strategy address several broad topics related to management of the sagebrush ecosystem. This science plan is organized around these topics and specifically focuses on fire, invasive plant species and their effects on altering fire regimes, restoration, sagebrush and greater sage-grouse (Centrocercus urophasianus), and climate and weather. The Strategy calls for the development of an actionable science plan (Plan hereafter) with prioritized research needs. For the purposes of this plan, “actionable” is defined three ways. First, the science community is able to take immediate actions to fill the identified science gaps. Second, science outcomes provide information that could directly inform actions taken by managers to protect, conserve, or restore the sagebrush ecosystem. Third, the Plan outlines the actions to facilitate the process of funding and implementing research efforts and effectively communicating research results to the management community. This definition of “actionable” is responsive to the tasks identified in the Strategy related to Science and Research (DOI 2015, Section 7(b)viii).