With increasing heat and droughts world-wide, wildfires are becoming a more serious global threat to the world’s population. Wildfire smoke is composed of approximately 80% to 90% of fine (<2.5 um) and ultrafine (<1 um) particulate matter (PM) which are also common to ambient pollution; these can penetrate the bloodstream through respiration. Population health studies indicate that wildfire smoke is a serious risk to human health and increases the healthcare burden of smoke-exposed areas. Wildfires increase asthma attacks, especially asthma hospitalization in children aged 0-5 years, and increase inflammation and cardiovascular events. Both respiratory and cardiovascular events are associated with inflammation.