Interactions between urban and wildfire pollution emissions are active areas of research, with numerous aircraft field campaigns and satellite analyses of wildfire pollution being conducted in recent years. Several studies have found that elevated ozone and particulate pollution levels are both generally associated with wildfire smoke in urban areas. We measured pollutant concentrations at two Utah Division of Air Quality regulatory air quality observation sites and a local hot spot (a COVID-19 testing site) within a 48 h period of increasing wildfire smoke impacts that occurred in Salt Lake City, UT (USA) between 20 and 22 August 2020. The wildfire plume, which passed through the study area during an elevated ozone period during the summer, resulted in increased criteria pollutant and greenhouse gas concentrations. Methane (CH₄) and fine particulate matter (PM_2.5) increased at comparable rates, and increased NO_x led to more ozone. The nitrogen oxide/ozone (NO_x/O₃) cycle was clearly demonstrated throughout the study period, with NO_x titration reducing nighttime ozone. These findings help to illustrate how the compounding effects of urban emissions and exceptional pollution events, such as wildfires, may pose substantial health risks. This preliminary case study supports conducting an expanded, longer-term study on the interactions of variable intensity wildfire smoke plumes on urban air pollution exposure, in addition to the subsequent need to inform health and risk policy in these complex systems.