Historical and contemporary policies and practices, including the suppression of lightning-ignited fires and the removal of intentional fires ignited by Indigenous peoples, have resulted in over a century of fire exclusion across many of the USA’s landscapes. Within many designated wilderness areas, this intentional exclusion of fire has clearly altered ecological processes and thus constitutes a fundamental and ubiquitous act of trammeling. Through a framework that recognizes four orders of trammeling, we demonstrate the substantial, long-term, and negative effects of fire exclusion on the natural conditions of fire-adapted wilderness ecosystems. In order to untrammel more than a century of fire exclusion, the implementation of active programs of intentional burning may be necessary across some wilderness landscapes. We also suggest greater recognition and accommodation of Indigenous cultural burning, a practice which Tribes used to shape and maintain many fire-adapted landscapes for thousands of years before Euro-American colonization, including landscapes today designated as wilderness. Human-ignited fire may be critical to restoring the natural character of fire-adapted wilderness landscapes and can also support ecocultural restoration efforts sought by Indigenous peoples.