For millennia, wildfire has helped shape the sagebrush biome of the western United States. Over recent decades, historical fire regimes have been altered by several factors, including contemporary climate and fuel conditions, leading to the loss or degradation of hundreds of thousands of hectares (ha) of sagebrush each year. In response to wildfire threats, extensive fuel treatment investments are proposed across the region. To help inform strategic and cost-effective investments, we conducted a quantitative assessment of wildfire risk for the sagebrush biome. We used a geospatial fire modeling approach, customized for the sagebrush biome, to estimate spatially explicit burn probability and expected average annual area burned within three Sagebrush Ecological Integrity classes under the Sagebrush Conservation Design: Core Sagebrush Areas (CSAs), Growth Opportunity Areas (GOAs), and Other Rangeland Areas. We further used indices of ecological resilience to disturbance and resistance to invasive grasses to characterize fire risk and recovery potential. Our approach indicates that nearly 530,000 ha are likely to burn in a typical contemporary fire year across the highest integrity Sagebrush Ecological Integrity classes (7% in CSAs and 31% in GOAs). Of the CSAs and GOAs likely to burn, nearly 9000 and 66000 ha, respectively, are expected to have low resilience or resistance and therefore highest loss potential. Cost-effective conservation investments should include wildfire protection for high-integrity sagebrush with low resilience or resistance. Protection objectives may be met with strategically placed fuel breaks intended to enhance fire prevention and containment efforts. Fuel treatments, including prescribed fire and mechanical activities outside of fuel breaks, are by contrast best suited for high-integrity areas with relatively high resilience and resistance. Those activities should be risk-informed and intended to maintain or improve ecological integrity and resilience to wildfire rather than to exclude fire altogether.