Intensification of drought and wildfire associated with climate change has triggered widespread ecosystem stress and transformation. Natural resource managers are on the frontline of these changes, yet their perspectives on whether management actions match the scale and align with the severity of ecosystem responses to improve outcomes are not well understood. To provide new insight, a new conceptual framework that linked scale and severity was tested by conducting interviews and surveys of staff associated with natural resource management on the Colorado Plateau in the southwestern United States (U.S.), which contains the highest concentration of public lands in the contiguous U.S. Results indicate that drought was experienced more frequently than wildfire, and both stressors were happening at large scales and moderate to abrupt timeframes with a high degree of impact to ecosystems. Ecosystem responses were perceived to increase in severity under future climate change with limited capacity to recover, and a majority of resource managers expressed that they had low control to shape these trajectories. Although management strategies to address drought and wildfire were well recognized, adaptation-specific actions remained unclear or had limited financial and staffing resources to support implementation. Additional effort could help close a growing misalignment between management actions and natural resource responses, including effective science communication, refined information tailored to meet adaptation goals at management-relevant spatiotemporal scales, and opportunities for adaptive management that can proactively address intensification of drought and wildfire.